Investigation of Microcavitation as a Neuronal Damage Mechanism in Blast Traumatic Brain Injury

Red-blue anaglyph (for 3D glasses) image of before and after microcavitation in a fibrous collagen network

Our fundamental understanding of cellular and tissue damage occurring during blast traumatic brain injuries (bTBI) is still in its infancy. This project focuses on the effect of microcavitation as a potential injury mechanism to cell cultures during simulated blast injuries. By combining high-speed imaging with digital image processing algorithms, this project investigates the physical nature of the deformation-driven cell injury signature on neurons in physiologically-realistic 3D culture settings.