In Vitro Traumatic Brain Injury Model to Assess Critical Mechanical Thresholds of Neural Network Signal Disruption 

Before (0-) and After (0+) 50% Applied Strain at 50 strain/second (playback 5X faster than real time).

2D neural culture seeded on polydimethylsiloxane (PDMS) dogbone at a density of 700,000 cells/mL.

30% Applied Strain and 7 Strain/Second (playback ~33X slower than real time).

Uniaxial stretch applied to PDMS dogbone with random speckle pattern.